-243x10y45
Rewrite -243 as (-3)5.
(-3)5x10y45
Rewrite x10 as (x2)5.
(-3)5(x2)5y45
Rewrite (-3)5(x2)5 as (-3×2)5.
(-3×2)5y45
(-3×2)5y45
Pull terms out from under the radical.
-3x2y45
Divide fifth root of -243x^10y^4
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